Chromatographic Silicon Dioxide (SiO₂) serves as the core stationary phase material in chromatographic separation technology, rigorously compatible with technical requirements for applications such as high-performance liquid chromatography (HPLC), gas chromatography (GC), thin-layer chromatography (TLC), and solid-phase extraction (SPE). Characterized by micron-sized spherical morphology, it features uniform particle size distribution, stable chemical properties, and high mechanical strength. The surface is rich in silanol groups, which can be modified through specific functional groups (e.g., C18/C8/polar groups) to adjust pH adaptability. This material is indispensable in separation and purification processes across pharmaceuticals, biotechnology, specialty chemicals, and related fields.

Table parameters

Application description

Relying on porous structure, high specific surface area and modifiable surface characteristics, silica for chromatography plays three core roles in the field of chromatographic separation:
1.Efficient separation: 60A pore diameter and high specific surface area design of 480-540m²/g to avoid small molecule exclusion, enhance the retention and separation efficiency of target substances, and facilitate precise operations such as impurity analysis and chiral separation;
2.Mode compatibility: the native silanol group is suitable for positive phase separation (polar substances such as alcohol/phenol/bioalkaloid), and can switch to reverse phase mode after bonding functional groups, compatible with HPLC, TLC, Flash chromatography and other equipment;
3.Stable Adaptation: Low metal impurities (Fe ≤ 0.02%) reduce tailing caused by alkaline substances, improve separation accuracy, and are easily regenerated through baking and solvent flushing, reducing material costs. Widely used in large-scale liquid chromatography for small molecule purification, API purification, and fine chemical purification scenarios.

Factory advantage

As a national high-tech enterprise and provincial-level specialized, refined, unique, and innovative enterprise, we have been deeply rooted in the industry for over two decades. Our company holds 17 patented technologies and operates a GMP-certified production base. Equipped with advanced testing instruments including atomic fluorescence spectrophotometers and laser particle analyzers, we have established a comprehensive quality control system comprising 26 inspection processes from raw materials to finished products. The company has obtained ISO22000 Food Safety Management System certification.
With core technologies in the R&D and production of chromatography-grade silica, we have established a comprehensive quality control system covering raw material screening to finished product manufacturing. This ensures consistent batch stability and performance across our product line. Our production facilities can meet customized demands for chromatography stationary phases from various industries, serving separation and purification applications in pharmaceuticals, specialty chemicals, and related fields.

Shipping packaging

•Standard packaging: 20KG/ bag, inner packaging to ensure product purity, avoid external pollution
•Customization options: negotiate packaging specifications and labels according to customer requirements, and consult the sales representative in advance
•Storage and transportation requirements: Due to the high specific surface area of the product, it is easy to absorb atmospheric water vapor or volatile substances, so it should be stored in a dry, ventilated and cool place; shelf life is 24 months. It is recommended to do application test before using after the expiration date
•Compliance mark: each package shall indicate the product model, batch number, key performance parameters, storage precautions and other information

Our Advantages

4.Customization capability: the aperture (to adapt to different molecular weight substances), particle size (to balance column efficiency and back pressure), and surface functional groups (to expand the pH range and separation mode) can be adjusted according to separate requirements
5.Performance guarantee: low metal impurities, narrow particle size distribution, high specific surface area and other indicators are precisely controlled to ensure the separation accuracy and stability, reduce the tailing of target substances
6.Full chain service: provide pre-sales technical consultation (such as model recommendation according to separation scenario), mid-sales production progress follow-up, and after-sales application support (such as activation and regeneration guidance)
7.Scenario adaptability: compatible with various chromatographic modes of positive phase and negative phase, covering pharmaceutical impurity analysis, purification of active ingredients of natural products, rapid preparation and other diversified needs
8.Cost advantage: the product is easy to activate and regenerate, prolong service life, reduce long-term use of consumables cost

Questions and answers

Q: Can you provide customized products with specific aperture or particle size? A: Yes, we can customize the aperture (such as to match different molecular weights of small molecules), particle size (such as to meet the requirements of specific column efficiency and back pressure) and surface functional group bonding in all dimensions.
Q: Which specific chromatographic techniques are suitable for the product? A: It can be widely used in high performance liquid chromatography (HPLC), gas chromatography (GC), thin layer chromatography (TLC) and solid phase extraction (SPE) and other mainstream chromatographic separation techniques.
Q: How to adjust the pH applicable range of the product? A: The pH applicable range in the original state is 2-8. By combining specific functional groups such as C18/C8/polar group with the surface hydroxyl group of silica gel, the applicable range can be extended to 1-12, which expands the application field.
Q: Can it be used after the expiration date? A: It is recommended that the storage period should not exceed 24 months. If it needs to be used after the expiration date, it should be applied first and the separation performance should meet the requirements before use.

Qualification Honor

•FSSC22000
•ISO22000：2018
•ISO9001：2015
•SHC HALAL
•OU  KOSHER
•FDA attestation 
•FAMI-QS
•SEDEX
•Food additive production license
•Feed additive production license
•National high-tech enterprise
•Specialized, refined and new enterprises in Guangzhou
•17 patents from the State Intellectual Property Office