1.1 Basic definitions
Zhongqi High Adsorption Oil-Resistant Silica, a pharmaceutical-grade excipient produced through an optimized precipitation-supercritical drying process, appears as a white, loose powder. Its core features include a three-dimensional interconnected porous structure and exceptional adsorption capacity, enabling rapid and efficient capture of oil-based active pharmaceutical ingredients (APIs) and excipients. The material maintains excellent flowability and stability post-adsorption while avoiding chemical reactions with drugs, making it a key solution for addressing formulation challenges in lipid-soluble pharmaceuticals.

1.2 Core values
As a multifunctional excipient specializing in food and pharmaceutical applications, Zhongqi High Absorbency Silica effectively addresses industry challenges such as crystallization of lipophilic APIs, layering in soft capsule contents, and poor compatibility in compound formulations. Through precise pore structure control, it achieves efficient loading and stable encapsulation of oily components, significantly enhancing formulation uniformity and shelf life.

Product Characteristics

2.1 Structural and performance advantages

•High efficiency adsorption capacity: oil absorption value can reach 250-360mL/100g, oil absorption rate is more than 90% within 10 minutes, can quickly absorb fish oil, vitamin E and other oily components.

•Stable coating performance: after adsorption of oily API, a stable solid dispersion is formed to prevent crystallization and precipitation of components, and the stability of preparation is significantly improved.

•Excellent flow characteristics: the three-dimensional mesh pore structure of the product gives the resting angle less than or equal to 35° after adsorption of oil components, which is suitable for high-speed tablet pressing and capsule filling process.

•Ultra-high purity guarantee: SiO₂ content is more than 99.0%(after burning), total heavy metal content is less than 30ppm, arsenic content is less than 8ppm, and microbial limit is less than 1000CFU/g, which meets the pharmaceutical grade purity requirements.

2.2 Process assurance
The product is manufactured through a three-step process combining sodium silicate and sulfuric acid neutralization with precipitation, followed by supercritical CO₂ drying. By precisely controlling the precipitation temperature and drying pressure, an interconnected pore structure is created. The entire production process strictly adheres to GMP standards, with each batch rigorously tested to ensure consistent quality control.

Key technical parameters

Application Fields

4.1 Soft capsule preparations
•Content stabilizer: Add 3-8% of oil-based API such as vitamin A/D/E and coenzyme Q10 to prevent the layering and oil leakage of contents, shorten the disintegration time of soft capsules to less than 15 minutes, and extend the shelf life to 36 months.
•Filling performance optimization: the oily content is converted into fluid powder, the filling error of capsule is reduced to less than ±2%, and the production efficiency is increased by 30% with high-speed filling equipment.

4.2 Solid dosage forms
•Fat-soluble tablets: As the adsorption carrier of oil-based API such as ibuprofen and simvastatin, adding 5-15% can improve powder flowability, increase tablet hardness by 20%, and reduce friability to <0.5%.
•Compound preparation: adsorb both oil and water soluble components at the same time to solve the compatibility problem of different polar components, so that the content uniformity of tablets is RSD <2%.

4.3 Nutritional supplements
•Fish oil /plant extract preparation: adsorb fish oil, flaxseed oil and other ingredients to make a tasteless solid powder, cover up bad odor, improve the palatability of products, and the retention rate of biological activity is more than 95%.
•Powdered detergent: As an anti-caking agent and adsorbent, 0.5-2.0% can be added to prevent the powder from absorbing moisture and lumping, maintain good flow, and adapt to the requirements of strip packaging and quantitative brewing.

Standards & Regulations

•Complies with multiple international pharmacopoeia standards: USP-NF, European Pharmacopoeia (Ph. Eur.), Japanese Pharmacopoeia (JP), and China Pharmacopoeia (ChP 2025).

•Obtain relevant qualification certification: FDA inactive ingredient database collection, EU E551 food additive certification.

•Comply with global compliance guidelines: comply with GMP production specifications and HACCP food safety system requirements.

Key points for handling and storage

•Adsorption operation: it is recommended to carry out adsorption at room temperature (20-25℃) and humidity <50%. Mix the product with oil components in proportion and stir for 15-20 minutes until complete adsorption. Avoid excessive shear damage to pore structure.

•Mixing process: the material after adsorption should be rapidly mixed with other auxiliary materials to ensure the uniformity of the preparation and adapt to direct tablet pressing and wet granulation process.

•Storage conditions: sealed packaging, stored in a dry and cool place (15-25℃, relative humidity <60%), avoid moisture affecting oil absorption performance, valid for 2 years, use up within 1 month after opening.

Product Advantages

•High oil absorption efficiency: Oil absorption value leads the industry standard, reduces the amount of auxiliary materials, reduces preparation cost, and is suitable for high concentration oil API system.

•Full scenario adaptation: compatible with soft capsules, tablets, granules and other dosage forms, can adsorb a variety of oil components from low viscosity essential oil to high viscosity oil.

•Global compliance guarantee: all indicators meet the requirements of international pharmacopoeia, support domestic and foreign drug and health product registration, accelerate the process of product marketing.

•Customized service: the oil absorption value and particle size parameters can be adjusted according to the characteristics of oily API, and exclusive adsorption scheme and process optimization guidance can be provided.

Enterprise system certification and honors

•FSSC22000
•ISO22000：2018
•ISO9001：2015
•SHC HALAL
•OU  KOSHER
•FDA attestation 
•FAMI-QS
•SEDEX
•Food additive production license
•Feed additive production license
•National high-tech enterprise
•Specialized, refined and new enterprises in Guangzhou
•17 patents from the State Intellectual Property Office