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Fumed Silica Glidant and Disintegrant
Zhongqi (Shandong) Silicon Materials Co., Ltd.'s ZLCSIL™ series pharmaceutical grade fumed silica is an ideal glidant and disintegrant for pharmaceutical formulations.
Fumed Silica: High-Efficiency Glidant and Disintegrant
Zhongqi (Shandong) Silicon Materials Co., Ltd.'s ZLCSIL™ series pharmaceutical grade fumed silica is an ideal glidant and disintegrant for pharmaceutical formulations. With its unique nanostructure and surface properties, it can significantly improve the production process and product quality of drug formulations.
Mechanism and Advantages as a Glidant:
Mechanism:
Nanoscale particles of fumed silica can be uniformly adsorbed on the surface of drug particles, forming a smooth isolation layer, significantly reducing friction and electrostatic force between particles, thereby greatly improving powder flowability.
Advantages:
- Excellent flow improvement effect achieved with extremely low addition levels (usually 0.1%-1.0%)
- Effectively improves the flowability of poorly flowing materials
- Increases tablet compression speed and production efficiency
- Reduces tablet weight variation and improves product uniformity
- Prevents powder stratification and ensures mixing uniformity
- Suitable for direct compression and dry granulation processes
Mechanism and Advantages as a Disintegrant:
Mechanism:
Fumed silica has an extremely high specific surface area and porous structure, which can quickly absorb water and form capillary channels, driving rapid water penetration into tablet cores and accelerating the tablet disintegration process.
Advantages:
- Significantly shortens tablet disintegration time
- Improves drug dissolution rate and bioavailability
- Has good synergistic effect with other disintegrants
- Does not affect tablet hardness and appearance
- Suitable for various types of solid dosage forms
Recommended Usage Methods:
- Glidant: Usually added in the final mixing stage, addition level 0.1%-1.0%
- Disintegrant: Can be used internally, externally, or a combination of both, addition level 0.5%-3.0%
- It is recommended to determine the optimal addition level and method through experiments
Product Selection:
- ZLCSIL™ PH200: General-purpose type, suitable for gliding and disintegration of most formulations
- ZLCSIL™ PH300: High-performance type, suitable for poorly flowing materials and rapid disintegration requirements
- ZLCSIL™ PH380: Premium type for special formulations and high-demand recipes
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