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14
2026
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04
Application of Mesoporous Silica in Targeted Anti-Cancer Therapy: iRGD Modification and Photothermal Synergistic Therapy Technology
Targeted cancer therapy represents a high-end application field of mesoporous silica nanoparticles (MSN).
Targeted cancer therapy represents a high-end application field of mesoporous silica nanoparticles (MSN). Through modification with iRGD peptides and polydopamine (PDA) coating, a synergistic effect of "targeted enrichment – penetration – photothermal therapy" can be achieved.
iRGD peptides contain both RGD sequences and CendR motifs. They first bind to the αvβ3 integrin receptors on tumor vascular endothelium, and then interact with neuropilin‑1 (NRP‑1) receptors via the CendR motif. This mechanism greatly enhances the permeability of the delivery vehicle in tumor tissue, increasing drug enrichment by more than 6‑fold.
The PDA layer serves two key functions:
It acts as a reactive platform to conjugate iRGD and the pH‑responsive material PEOZ, enabling triggered drug release in acidic tumor microenvironments.
It exhibits excellent photothermal conversion efficiency. Under near‑infrared (NIR) irradiation, it converts light energy into thermal energy, raising local tumor temperature above 42 °C to ablate cancer cells. Combined with chemotherapy, this synergistic system boosts cancer cell apoptosis rate to 80%.
Our company demonstrates outstanding technological advantages in system integration. The developed MSN@PDA‑PEOZ‑iRGD drug delivery system achieves a drug loading capacity of up to 35% and a pH‑responsive release rate of over 90% (at pH 5.5). It has completed in vitro cell experiments and mouse model verification. Two invention patents have been granted for the related technologies, and preclinical collaborations are underway with multiple oncology hospitals.
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