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08
2026
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04
Surface Modification Technology of Pharmaceutical-Grade Silicon Dioxide: Improving Drug Compatibility and Targeting Efficiency
The surface modification technology of pharmaceutical-grade silicon dioxide is the key to expanding its application boundaries.
The surface modification technology of pharmaceutical-grade silicon dioxide is the key to expanding its application boundaries. By introducing functional groups, the drug compatibility and targeting efficiency can be significantly improved. For hydrophobic drugs (such as paclitaxel), amino modification using a silane coupling agent (APTES) changes the carrier surface from hydrophobic to hydrophilic, and the drug loading capacity is increased to 30% (compared with only 15% for unmodified silicon dioxide).
For targeted drug delivery requirements, ligand modification can be carried out: tumor-targeting peptides (such as iRGD) are linked to the carrier surface through Schiff base reaction, so that the carrier can specifically recognize the αvβ3 integrin receptor of tumor cells, the drug concentration in the tumor site is increased by more than 5 times, and the toxicity to normal tissues is reduced. In addition, modification with polyethylene glycol (PEG) can prolong the circulation time of the carrier in vivo and avoid being cleared by the reticuloendothelial system.
The Company has mature modification technology: it can provide more than 10 modification schemes, including amino groups, carboxyl group and sulfhydryl group, with a modification efficiency of more than 95% and good batch stability. For the needs of antibody-drug conjugate (ADCs), it has developed a "dual-function modified" carrier, which has both drug loading and targeted recognition functions, and has carried out cooperative research and development with many innovative pharmaceutical companies.
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Jinan City, Shandong Province,China
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Guangzhou City, Guangdong Province
