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02
2026
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04
Application of Mesoporous Silica in Sustained and Controlled Release Preparations: Pore Size Tuning and Release Mechanism Optimization
Sustained and controlled release preparations are designed to achieve uniform drug release and stable plasma drug concentration.
Sustained and controlled release preparations are designed to achieve uniform drug release and stable plasma drug concentration. Owing to its tunable pore structure, mesoporous silica has become a core carrier material, where pore size directly determines the drug release rate.
Carriers with a pore size of 2–5 nm are suitable for small-molecule drugs (e.g., aspirin), providing a release duration of up to 8 hours. Carriers with 10–20 nm pores match middle-molecule drugs (e.g., ibuprofen), enabling 12-hour sustained release. Carriers in the 20–50 nm range are used for macromolecular protein drugs, preventing sharp plasma concentration fluctuations caused by excessively rapid release.
The release mechanism can be further optimized via surface modification:
After modification with pH-responsive materials (e.g., PEOZ), the carrier remains intact in the stomach and releases the drug only upon entering the intestinal tract, thereby reducing irritation to the gastric mucosa. When modified with temperature-responsive materials, the release timing can be precisely controlled via external heating.
In addition, adjusting the carrier particle size to 50–200 μm enables the transition from systemic delivery to local targeted delivery.
The Company’s core technological advantage lies in precision pore size control. Using the sol-gel method combined with templating technology, the pore size deviation is controlled to ≤ 1 nm, and the specific surface area can exceed 800 m²/g.
We have developed dedicated sustained and controlled release carriers for antihypertensive and hypoglycemic drugs, achieving a drug release coefficient of variation (CV) below 5%. This supports pharmaceutical companies in developing long-acting formulations and reducing patient dosing frequency.
The news and information released by Zhonglian Chemical is provided solely for informational purposes and is intended only for reference and communication among industry professionals. It does not guarantee the accuracy and completeness of such information. You should not use this information to replace your own independent judgment; therefore, you shall bear the risks arising from any use of the information, and Zhonglian Chemical shall not be held liable. In case of any infringement, please contact us for removal.
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Jinan City, Shandong Province,China
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Guangzhou City, Guangdong Province
