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2026
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Application of Gel-Method Silicon Dioxide in Medicine: Breakthrough in High-End Scenarios of High-Purity Carrier Materials
Gel-method silicon dioxide has become the first choice for high-end excipients in the pharmaceutical field due to its high purity and regular pore structure, and its production process and performance are significantly better than traditional precipitation-method products.
Gel-method silicon dioxide has become the first choice for high-end excipients in the pharmaceutical field due to its high purity and regular pore structure, and its production process and performance are significantly better than traditional precipitation-method products. The gel method is formed by sol-gel conversion under acidic conditions, with smaller primary particle size (<20nm), specific surface area up to 200-1000m²/g, uniform pore distribution, and general purity ≥99.5%, while precipitation-method products mostly have a purity of 95%-98% and a wide pore distribution.
In medicinal scenarios, gel-method products are mainly used in two major fields: first, as a drug carrier, its porous structure can load active ingredients such as vitamins and probiotics, protect them from gastric acid erosion. For example, when used in vitamin C preparations, it can increase the bioavailability by 30%; second, as a sustained and controlled release excipient, it controls the drug release rate by adjusting the pore size. For example, in nifedipine sustained-release tablets, it can achieve 12-hour uniform drug release.
The Company's technological breakthrough lies in high-end customization: the developed "medicinal-grade gel silica" has a purity of 99.8% and a heavy metal content of less than 5mg/kg, has passed GMP certification and pharmacopoeia infrared spectrum identification, provides models with adjustable pore size of 3-50nm according to different drug characteristics, has become the core excipient for high-end sustained-release preparations of many domestic pharmaceutical companies, and broken the monopoly of imported products.
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