Welcome to Shandong Zhonglian Chemical Co., Ltd. Equity Code:880747
24
2026
-
03
Glidant and Disintegration Functions of Pharmaceutical-Grade Silicon Dioxide in Tablets: Preparation Optimization Scheme Under Pharmacopoeia Standards
In tablet production, pharmaceutical-grade silicon dioxide ensures the quality of preparations through the dual functions of glidant and disintegration.
In tablet production, pharmaceutical-grade silicon dioxide ensures the quality of preparations through the dual functions of glidant and disintegration, and its performance indicators must meet the requirements of the Chinese Pharmacopoeia (ChP) 2020 Edition: SiO₂ content ≥99.0%, the proportion of particle size passing through the No.7 sieve (125μm) is not less than 85%, and pH value is 5.0-7.5.
The glidant effect is aimed at the granulation link: powdered active pharmaceutical ingredients (APIs, such as aspirin) have poor fluidity, which easily leads to uneven filling. After adding 0.1%-0.3% medicinal silicon dioxide, it can fill the gaps between particles, reduce the angle of repose to below 30°, control the tablet weight difference within ±2%, and avoid the problems of "loose tablets" and "sticking" during tableting. The disintegration function relies on its high specific surface area: it quickly adsorbs water and expands when encountering water, destroys the internal structure of the tablet, shortens the disintegration time from 15 minutes to less than 5 minutes, and improves the drug dissolution rate.
The Company's product advantages are reflected in functional adaptation: it has developed a "high adsorption glidant type" for oil extract drugs and a "fast disintegration type" for poorly soluble drugs. Among them, the fast disintegration type has a specific surface area of 350m²/g, and its disintegration efficiency is 20% better than the industry average. Each batch of products is provided with infrared spectrum identification and loss on ignition test reports to ensure compliance with pharmacopoeia standards and help pharmaceutical companies pass the consistency evaluation.
Related Blog
Related Downloads
Service E-mail
Sales Add
Jinan City, Shandong Province,China
Production Add
Guangzhou City, Guangdong Province
