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17
2026
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03
Mesoporous Silica Nanocarrier: Technological Breakthrough of pH-Responsive Targeted Drug Delivery System
Mesoporous silica (pore size 2-50nm) has become the core carrier for anti-tumor drug delivery due to its high drug loading capacity and easy surface modification. The pH-responsive modification technology is solving the pain point of "off-target release" of traditional carriers. The pH of tumor tissue is approximately 6.5, and the pH of lysosomes is as low as 5.0-5.5. Based on this, the developed MSN@PDA-PEOZ-iRGD drug delivery system can achieve precise regulation of "circulation stability-targeted enrichment-triggered release".
The system uses mesoporous silica as the core, wraps a polydopamine (PDA) layer as a reaction platform, and connects the pH-responsive material PEOZ and the tumor-penetrating peptide iRGD: PEOZ remains stable in a neutral environment, and degrades rapidly after entering the acidic tumor area to release the drug; iRGD binds to the αvβ3 integrin receptor of tumor cells to improve the permeability and retention time of the carrier. At the same time, the photothermal conversion properties of PDA can achieve the synergistic effect of "chemotherapy + photothermal therapy", and in vitro experiments show that the apoptosis rate of tumor cells is increased by 40%.
The Company's technical advantages are reflected in the development of customized carriers: the mesoporous pore size can be adjusted according to the size of drug molecules (adjustable from 3-50nm), the surface modification efficiency is over 90%, and the maximum drug loading capacity can reach 35% (mass ratio). It has provided targeted drug delivery carrier solutions for lung cancer and breast cancer for many pharmaceutical companies, and the related processes have obtained 3 invention patents.
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Jinan City, Shandong Province,China
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