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2025
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ZLXIDE™ Pharmaceutical Excipient Silicon Dioxide - A Benchmark of Multifunctional and Compliant Excipients Empowering the Pharmaceutical Industry
Supported by compliance, performance, and services, ZLXIDE™ is committed to promoting the high-quality development of the industry and looks forward to cooperating for mutual success!
In the high-quality development of the pharmaceutical, health product, and cosmetics industries, the compliance, stability, and multifunctionality of excipients are crucial. The ZLXIDE™ series of pharmaceutical excipient silicon dioxide strictly adheres to the Chinese Pharmacopoeia 2020 Edition Volume IV (First Supplement) and has become a core excipient choice with outstanding performance.
I. Core Advantages: Compliance as the Foundation, Performance as the Core
1. Authoritative Compliance & Safe Controllability
- Standard Compliance: Complies with the Chinese Pharmacopoeia 2020 Edition Volume IV and its First Supplement, with clear classification between Regular Grade (CAS: 14464-46-1) and Colloidal Grade (CAS: 112945-52-5).
- High Purity: SiO₂ content ≥99.0% after ignition for Regular Grade, 99.0%-100.5% for Colloidal Grade; Heavy Metals ≤30ppm, Arsenic Salt ≤3ppm.
- Reliable Process: Full-process traceability. Regular Grade is refined by precipitation, while Colloidal Grade is prepared via exclusive processes with extremely low impurities.
2. Multifunctional Integration & Adaptability to Diverse Needs
Integrates multiple functions including glidant, anti-caking, thickening, stabilizing, drug-loading, and sustained-release. It solves pain points such as poor fluidity, caking, and uneven drug release, optimizing production processes and product quality.
II. Core Product Series: Precisely Segmented Scenarios
Covers 11 models, divided into two categories: Regular Grade (for conventional formulations) and Colloidal Grade (for high-end formulations):
1. Regular Grade: Preferred for Conventional Use
| Model | Core Features | Key Indicators | Application Scenarios |
| ZLXIDE™P58EP | High oil absorption, high fluidity | Specific Surface Area: 260-300m²/g, D50: 8-50μm | General formulations for pharmaceuticals, food, and cosmetics |
| ZLXIDE™P58BT | Outstanding stability | Specific Surface Area: 230-320m²/g, D50: 20μm | Vitamins, health products |
| ZLXIDE™P350 | High oil absorption + high specific surface area | Specific Surface Area: 260-350m²/g, D50: 8-50μm | High-activity, oil-based pharmaceutical formulations |
| ZLXIDE™P63FP/P1FP | Dual effects of anti-caking + glidant | Specific Surface Area: 85-300m²/g, D50: 4-10μm | Powders, granules, capsule filling |
| ZLXIDE™P244FPZLXIDE™P260S | Prepared by gel method, excellent dispersibility | Specific Surface Area: 230-300m²/g, D50: 4-10μm | Precision solid formulations |
Common Advantages: Pass rate through No.7 sieve ≥85%, pH 5.5-7.5, Loss on Drying ≤7.0-8.5%, strong compatibility.
2. Colloidal Grade: Exclusive for High-end Formulations
Core models: ZLXIDE™P200/P300/P380/P972. Nanoscale particle size (7-16nm), specific surface area 130-380m²/g, SiO₂ ≥99.8%; equipped with functions such as targeted delivery and controlled-release solubilization, suitable for targeted, nano, and high-purity formulations.
III. Full-scenario Applications: Covering the Entire Pharmaceutical Industry Chain
- Solid Formulations: Improves tableting qualification rate via glidant effect, extends shelf life with anti-caking property, ensures precise drug dosage retention.
- Liquid Formulations: Stabilizes and thickens to prevent aggregation and sedimentation, avoids stratification.
- Semi-solid Formulations: Adjusts viscosity, optimizes application experience.
- Novel Formulations + Health Products: Empowers R&D of targeted and controlled-release products, stabilizes the activity of health product ingredients.
IV. Quality Control & Assurance: Safeguarding Quality Throughout the Process
1. Comprehensive Quality Control
| Test Item | Regular Grade Standard | Colloidal Grade Standard |
| Particle Size / Loss on Drying | ≥85% / ≤5.0% | ≥85% / ≤2.5% |
| pH Value / Loss on Ignition | 5.0-7.5 / ≤8.5% | 3.5-5.5 / ≤8.5% |
| Chloride / Sulfate / Iron Salt | ≤0.1% / ≤0.5% / ≤0.015% | ≤0.1% / ≤0.5% / ≤0.015% |
2. Scientific Storage & Usage
Addition amount: 0.1%-5.0%; store in airtight and dry warehouse (humidity ≤60%); shelf life: 24 months; packaged in 10/15kg airtight containers, protected from moisture and contamination.
V. Enterprise Support: Professional Empowerment for Win-Win Cooperation
Shandong Zhonglian Chemical provides:
- Free samples and compatibility testing
- One-on-one technical support and customized solutions
- Complete quality certificates and TDS documents
Supported by compliance, performance, and services, ZLXIDE™ is committed to promoting the high-quality development of the industry and looks forward to cooperating for mutual success!
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Jinan City, Shandong Province,China
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