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07
2025
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01
Silica: A Multifunctional Core Material in Medical Gels
Silica also possesses functional value in specialized medical gels. In dental restorative gels, it can enhance the bond between the gel and tooth tissue
Due to its excellent biocompatibility, porous structure, and physicochemical stability, silica has become a key component in the medical gel field. It plays an irreplaceable role in wound repair and drug delivery, providing core support for the functional upgrade of medical gels.
Silica is an ideal functional modulator in gel matrix optimization. Its nanoparticles form hydrogen bonding networks with the gel's polymer chains through surface hydroxyl groups, significantly enhancing the gel's mechanical strength and adhesion, preventing the gel from shedding during wound activity. Furthermore, its porous structure endows the gel with excellent water absorption and retention capabilities, maintaining a moist microenvironment at the wound surface and creating conditions for tissue regeneration. For example, in burn care gels, adding 2%-5% fumed silica can increase the gel's water retention by over 30%, extending the dressing change interval.
As a drug carrier, silica provides a solution for targeted gel delivery. Mesoporous silica, with a surface area exceeding thousands of m²/g, can efficiently load active ingredients such as antibiotics and growth factors, achieving sustained drug release through pore size control. In chronic wound gels, gentamicin-loaded mesoporous silica can extend the drug release period to 72 hours, reducing infection recurrence. Furthermore, its surface can be modified with targeting groups to precisely concentrate the drug at the lesion site.
Silica also possesses functional value in specialized medical gels. In dental restorative gels, it can enhance the bond between the gel and tooth tissue; in biodegradable hemostatic gels, its particles can activate coagulation factors and accelerate hemostasis.
With the advancement of material modification technology, functionalized silica (such as hydroxylation and amino modification) is driving the intelligentization of medical gels, showing broad application prospects in precision medicine.
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